ABSTRACT
The treatment of refractory Glaucoma is a difficult problem in clinical ophthalmology. For refractory glaucoma patients with hyphema, shallow anterior chamber, anterior conglutination of peripheral chamber angle, corneal endothelium dystrophy or decompensated, at present, there is no effective treatment. In order to solve this problem, a new type posterior integral glaucoma valve with IOP control device was designed using medical titanium alloy, and the valve model was established by Abaqus software, and the stiffness and preload of the valve were analyzed by finite element method. The results showed that the opening and closing of the valve were controlled automatically by the pressure difference between the front and back of the valve, and the opening and flow rate of the valve increase dynamically with the increase of intraocular pressure, and finally reached the set ideal IOP value of steady state.
Subject(s)
Humans , Finite Element Analysis , Follow-Up Studies , Glaucoma , Glaucoma Drainage Implants , Intraocular Pressure , Treatment OutcomeABSTRACT
Based on the biomechanical mechanism of human upper limb, the disadvantages of traditional rehabilitation training and the current status of upper limb rehabilitation robot, a six degree of freedom, flexible adjustment, wearable upper limb rehabilitation exoskeleton design scheme is proposed. Firstly, the mechanics of each joint of the upper limb is analyzed, and the virtual prototype design of the whole mechanical structure of the upper limb rehabilitation wearable exoskeleton is carried out by using CATIA three-dimensional software. The tooth transmission of the forearm and the upper arm single row four point contact ball bearing with internal/external rotation and the shoulder flexible passive adjustment mechanism (viscoelastic damper) are innovatively designed. Then, the joints of the upper limb rehabilitation exoskeleton are analyzed, theoretical analysis and calculation of the driving torque, the selection of the motor and gearbox of each driving joint are carried out. Finally, the whole finite element analysis of the upper limb exoskeleton is carried out. The research and experimental results showed that the design scheme of the upper limb exoskeleton assist structure is highly feasible, which can help the patients with upper limb paralysis and motor dysfunction self-rehabilitation.
Subject(s)
Humans , Biomechanical Phenomena , Exoskeleton Device , Robotics , Stroke Rehabilitation , Torque , Upper Extremity , Wearable Electronic DevicesABSTRACT
An auxiliary dining robot is designed in this paper, which implements the humanoid feeding function with theory of inventive problem solving (TRIZ) theory and aims at the demand of special auxiliary nursing equipment. Firstly, this robot simulated the motion function of human arm by using the tandem joints of the manipulator. The end-effector used a motor-driven spoon to simulate the feeding actions of human hand. Meanwhile, the eye in hand installation style was adopted to instead the human vision to realize its automatic feeding action. Moreover, the feeding and drinking actions of the dining robot were considered comprehensively with the flexibility of spatial movement under the lowest degree of freedom (DOF) configuration. The structure of the dining robot was confirmed by analyzing its stresses and discussing the specific application scenarios under this condition. Finally, the simulation results demonstrate high-flexibility of the dining robot in the workspace with lowest DOF configuration.
Subject(s)
Humans , Computer Simulation , Equipment Design , Hand , Movement , Robotics/methodsABSTRACT
OBJECTIVE: To summarize the structural design strategy and safety assessments of rAAV packaging systems. METHODS: Based on the research progress and international review experience of commercial rAAV products, the design strategy and safety assessments of rAAV packaging systems were summarized. The design strategy and safety assessments of rAAV packaging systems were summarized. RESULTS: The scientific evaluation of the pharmaceutical design of rAAV for human should cover multiple aspects, because various types of AAVs differ in tissue selectivity, viral assembly, transgene expression. Meanwhile, the packaging system is diverse, and the production process is complex. CONCLUSION: The considerations referring to the rAAV structure and mechanisms of producing replication-competent AAV are proposed, and we hope to improve the communications between developers and regulators.
ABSTRACT
Objective To develop a novel electric stapler, so as to improve the automation, convenience and precision of minimally invasive surgery. Methods The clamping, firing and turning mechanism of the new electric stapler was innovatively designed to realize the electric drive of minimally invasive surgical anastomosis on the basis of traditional mechanical stapler. The motion process of electric clamping, firing and double-screw turning mechanism was analyzed in detail, and the equations for motion function of three mechanisms were solved, providing a theoretical basis for the intelligent control algorithm of electric stapler. Results The electric clamping and firing process was simulated using ADAMS software to verify the equation of motion. The prototype of the new electric stapler was made, and the anastomosis experiment and blasting pressure experiment of the in vitro small intestine tissues were carried out. The range of anastomotic blasting pressure was between 3.7 kPa and 11.67 kPa, meeting the basic requirements in clinic. Conclusions The structure of the new electric stapler can meet the requirements of electric pressing and firing in minimally invasive surgery, contributing to achieve tissue anastomosis more conveniently, quickly and effectively.
ABSTRACT
Objective To design a space crawl training device.This device could achieve oval movement by rotating the wheel to drive the handle of the upper limb.At the same time,the leg support is driven to rotate about 30 degrees to 0 de-grees,which can assist the user to complete the entire crawling. Methods The structure of the device was modeled using SolidWorks.Then the whole device was simulated by using SolidWorks Motion,and the dynamic analysis was completed by calculation.Finally,the main force components from SolidWorks were imported into ANSYS Workbench for static analysis. Results and Conclusion The designed space trajectory crawling training device can assist the user to complete the scheduled crawling movement,and the strength checking of the key components meets the strength requirements.
ABSTRACT
During the past decade, the anchorage implants have been widely used in the orthodontic treatment. Many scholars have studied the influence of different factors on anchorage implant's primary stability, including anchorage implant's material properties, structural design, surgical procedure, bone condition, loading force's magnitude and direction. This article is to review the influence of anchorage implant's shape, dimension, neck design and thread design on its primary stability.
ABSTRACT
Pill and powder with obvious characteristics are the main dosage forms of traditional Chinese materia medica. The two dosage forms have principles and characteristics in selection of diseases, processing, and in vivo release of prescriptions. But the development was limited because of the decrease of compliance of patients due to shortages like crude preparation process and large dosage. To combine with the characteristics of traditional pill and powder, authors suggest a new technology in pharmaceutics through practice, that is particles design technology for Chinese materia medica. In this article, the basic concept and features, basic principles, implementation methods, intended use of the ten aspects on particles design technology for Chinese materia medica are discussed in detail. Authors believe that the new research ideas on the quality improvement and industrial upgrading for the traditional pill and powder will be put forward in this new technology.